This ‘Farewell symposium' will celebrate Prof. dr. M. Danhof’s professional career and all the high level contributions he has made to the area of Pharmacology.’ The symposium will be followed by the farewell lecture of Professor Danhof and a reception.
Reflections on pharmacology
“Pharmacokinetics & Pharmacodynamics” en route to “Systems Pharmacology”
Over the years pharmacology has contributed important pharmacokinetic (PK) and pharmacodynamic (PD) modeling concepts that are widely utilized in drug discovery & development research and in clinical practice. At this symposium the established as well as the emerging novel concepts in pharmacology will be reviewed.
At the level of the pharmacodynamics, between 1960 to 1970, the development of receptor theory concepts has yielded the basis for the understanding of in vivo drug-concentration-effect relations. Next, in particular progress in the pharmacokinetics has been the source of novel concepts. Major achievements in pharmacokinetics include: i) the elucidation of the molecular mechanisms of drug disposition (i.e. drug metabolizing enzymes and transporters), ii) the development of pharmacokinetic modeling concepts including the introduction of physiology-based pharmacokinetic (PBPK) modeling for the prediction of in vivo drug concentration profiles, iii) the identification of inter-individual variation in drug disposition as the basis for variation in drug response (and the introduction of the concepts of “population” pharmacokinetics), and iv) the introduction of pharmacokinetic-pharmacodynamic modeling (PKPD) concepts as the basis for prediction of the time course of drug effects.
Nowadays pharmacokinetic and pharmacodynamic modeling concepts are routinely used as the basis for the development of new drugs. Moreover PKPD modeling has become a standard requirement for the regulatory approval of a drug. Yet new concepts continue to emerge. The most recent developments in pharmacology are directed to the interfacing with systems biology. Novel Systems Pharmacology concepts are introduced, which yield a scientific basis for the design, the development and the clinical usage of ‘precision treatments’ aimed at disease modification.
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