Innovative artery-on-a-chip system by Mimetas and LACDR opens new avenues for drug development
Smart microscale technology
Researchers at Mimetas (Oegstgeest) and the Leiden Academic Centre for Drug Research (LACDR) have co-developed an advanced artery-on-a-chip model. This microfluidic system consists of 48 channels lined with human coronary artery cells. What sets it apart is the use of gravity-driven unidirectional flow. A simple, natural method for circulating fluid through the chip, without pumps or complex equipment.
Mimicking healthy and diseased vessels
The chip simulates both healthy and pathological conditions. Under unidirectional flow, cells exhibit a stable, aligned structure, mimicking healthy arteries. Under bidirectional (reversing) flow - often found in deseased vessels - the model induces stress: fibronectin builds up, inflammatory signals activate, and vessel walls constrict.
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UniFlow-technology™: stable flow without pumps
At the heart of this innovation lies Mimetas' patented UniFlow technology. It enables continuous unidirectional flow using gravity alone, eliminating the need for external pumps or valves. This reduces complexity, minimizes mechanical stress on cells, and makes the system easier to scale. UniFlow provides a robust foundation for reproducible, long-term experiments in laboratory settings.
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Capturing inflammation and disease progression
The model enables researchers to introduce inflammatory cytokines like TNF-α and IL-1β- and study cellular responses. This reveals how diseases develop at a molecular level: increased IL-6, ICAM-1 expression, and lipid accumulation were observed under diseased flow. Such insights help identify new therapeutic targets and refine treatment strategies.
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Scalable and ethical research platform
With 48 channels, the system allows for high-throughput drug screening. Its simplicity makes it suitable for routine use in pharmaceutical research. Importantly, it supports ethical innovation by significantly reducing reliance on animal testing, aligning with the 3Rs of research: Replacement, Reduction and Refinement.